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X Chromosome Screen

(Under Construction)

Genetic Technology

(Under Construction)

Sequencing Technology

(Under Construction)

Identifying Key Regulators of Notch Signaling

(Under Construction)

Discovering Genes Required for Neuronal Maintenance

(Under Construction)

Related Publications

  1. Yamamoto S† (2020) Making sense out of missense mutations: Mechanistic dissection of Notch receptors through structure-function studies in Drosophila. Dev Growth Differ. 62:15-34. PMID: 31943162. PMCID: PMC7401704. (†corresponding author).

  2. Graves HK, Jangam S, Tan KL, Pignata A, Seto ES, Yamamoto S†, Wangler MF† (2020) A genetic screen for genes that impact peroxisomes in Drosophila identifies candidate genes for human disease. G3 (Bethesda). 10:69-77. PMID: 31767637, PMCID: PMC6945042. (†corresponding authors).

  3. Deal SL, Yamamoto S† (2018) Unraveling novel mechanisms of neurodegeneration through a large-scale forward genetic screen in Drosophila. Front Genet. 9:700. PMID: 30693015, PMCID: PMC6339878. (†corresponding author).

  4. Luo X, Rosenfeld JA, Yamamoto S, Harel T, Zuo Z, Hall M, Wierenga KJ, Pastore MT, Bartholomew D, Delgado MR, Rotenberg J, Lewis RA, Emrick L, Bacino CA, Eldomery MK, Coban Akdemir Z, Xia F, Yang Y, Lalani SR, Lotze T, Lupski JR, Lee B, Bellen HJ, Wangler MF; Members of the UDN (2017) Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially. PLoS Genet. 13:e1006905. PMID: 28742085. PMCID: PMC5557584.

  5. Cook M, Cazin C, Amoyel M, Yamamoto S, Bach E, Nystul T (2017) Neutral Competition for Drosophila Follicle and Cyst Stem Cell Niches Requires Vesicle Trafficking Genes. Genetics. 206(3):1417-1428. PMID: 28512187. PMCID: PMC5500140.

  6. Yoon WH, Sandoval H, Nagarkar-Jaiswal S, Jaiswal M, Yamamoto S, Haelterman NA, Putluri N, Putluri V, Sreekumar A, Tos T, Aksoy A, Donti T, Graham BH, Ohno M, Nishi E, Hunter J, Muzny DM, Carmichael J, Shen J, Arboleda VA, Nelson SF, Wangler MF, Karaca E, Lupski JR, Bellen HJ (2017) Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration. Neuron. 93(1):115-131. PMID: 28017472. PMCID: PMC5242142.

  7. Chen K, Lin G, Haelterman NA, Duraine L, Li Z, Graham BH, Jaiswal M, Yamamoto S, Bellen HJ (2015) Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. eLife. 5:e16043. PMID: 27343351. PMCID: PMC4956409.

  8. Li T, Giagtzoglou N, Fan J, Jia J, Yamamoto S, Charng W-L, Jaiswal M, Sandoval H, Bayat V, Xiong B, Zhang K, David G, Wei W, Lewis MT, Groves AK, Bellen HJ (2016) Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination. PLoS Genet. 12(5):e1006054. PMID: 27195754. PMCID: PMC4873228.

  9. David-Morrison G, Xu Z, Rui YN, Charng WL, Jaiswal M, Yamamoto S, Xiong B, Zhang K, Sandoval H, Duraine L, Zhang S, Bellen HJ (2016) WAC regulates mTOR activity through the TTT-Pontin/Reptin complex. Dev Cell. 36(2):139-151. PMID: 26812014. PMCID: PMC4730548.

  10. Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, Yamamoto S, Cooper TA, Graham BH, Bellen HJ (2015) Impaired mitochondrial energy production causes light induced photoreceptor degeneration independent of oxidative stress. PLoS Biol. 13(7):e1002197. PMID: 26176594. PMCID: PMC4503542.

  11. Tian X, Gala U, Zhang Y, Shang W, Nagarkar-Jaiswal S, di Ronza A, Jaiswal M, Yamamoto S, Sandoval H, Duraine L, Sardiello M, Sillitoe RV, Venkatachalam K, Fan H, Bellen HJ, Tong C (2015) A voltage gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol. 13(3):e1002103. PMID: 25811491. PMCID: PMC4374850.

  12. Liu L, Zhang K, Sandoval H, Yamamoto S, Jaiswal M, Sanz E, Li Z, Hui J, Graham BH, Quintana A, Bellen HJ (2015) Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration. Cell. 160(1-2):177-190. PMID: 25594180. PMCID: PMC4377295.

  13. Sandoval H, Yao CK, Chen K, Jaiswal M, Donti T, Lin YQ, Bayat V, Xiong B, Zhang K, David G, Charng W-L, Yamamoto S, Duraine L, Graham BH, Bellen HJ (2014) Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production. eLife. 3:e03558. PMID: 25313867. PMCID: PMC4215535.

  14. Haelterman NA, Jiang L, Li Y, Bayat V, Sandoval H, Ugur B, Tan KL, Zhang K, Bei D, Xiong B, Charng W-L, Busby T, Jawaid A, David G, Jaiswal M, Venken KJT, Yamamoto S, Chen R, Bellen HJ (2014) Large-scale identification of chemically induced mutations in Drosophila melanogaster. Genome Res. 24(10):1707-1718. PMID: 25258387. PMCID: PMC4199363.

  15. Yamamoto S*, Jaiswal M*, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LE, de Ligt J, Jhangiani SN, Xie Y, Tsang SH, Parman Y, Sivaci M, Battaloglu E, Muzny D, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Link N, Schulze KL, Boerwinkle E, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF, Bellen HJ (2014) A Drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell. 159(1):200-214 . PMID: 25259927, PMCID: PMC4298142. (*equal contribution).

  16. Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng W-L, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ (2014) The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol. 12(4):e1001847. PMID: 24781186, PMCID: PMC4004542.

  17. Charng W.-L, Yamamoto S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Gibbs S, Lu H.-C, Chen K, Giagtzoglou N, Bellen HJ (2014) Drosophila Tempura, a novel protein prenyltransferase-alpha subunit, regulates Notch signaling via Rab1 and Rab11. PLoS Biol. 12(1): e1001777. PMID: 24492843. PMCID: PMC3904817.

  18. Giagtzoglou N, Li T, Yamamoto S, Bellen HJ (2013) dEHBP1 regulates Scabrous secretion during Notch mediated lateral inhibition. J Cell Sci. 126(16):3686-3696. PMID: 23788431. PMCID: PMC3744027.

  19. Yamamoto S, Bayat B, Bellen HJ, Tan C (2013) Protein Phosphatase 1ß limits ring canal constriction during Drosophila germline cyst formation. PLoS One. 8(7):e70502. PMID: 23936219, PMCID: PMC3723691.

  20. Zhang K, Li Z, Jaiswal M, Bayat V, Xiong B, Sandoval H, Charng W-L, David D, Haueter C, Graham BH, Yamamoto S, Bellen HJ (2013) The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. J Cell Biol. 200(6):807-820. PMID: 23509070, PMCID: PMC3601355.

  21. Xiong B, Bayat V, Jaiswal M, Zhang K, Sandoval H, Charng W-L, Li T, David G, Haueter C, Yamamoto S, Bellen HJ (2012) Crag, a GEF for Rab11, is required for rhodopsin trafficking and the maintenance of Drosophila photoreceptor cells. PLoS Biol. 10(12): e1001438. PMID: 23226104, PMCID: PMC3514319.

  22. Yamamoto S, Charng W-L, Rana NA, Kakuda S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Wang H, Haltiwanger RS, Bellen HJ (2012) A mutation in EGF repeat of Notch discriminates between Serrate/Jagged and Delta ligand families. Science. 338(6111): 1229-1232. PMID: 23197537, PMCID: PMC3663443.

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