Celebrating the 100th anniversary of the publication of the first textbook on genetics titled "The Mechanism of Mendelian Heredity" by Morgan, Sturtevant, Muller and Bridges in 1915, we discuss how the pioneering work by these four prominent geneticists built the foundation of modern genetics, and how their legacy continues to impact people's lives, especially focusing on the utility of Drosophila in human disease research.
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