By generating the first clean knockout alleles of the fly genes that correspond to human TM2D1 (biscotti), TM2D2 (amaretto) and TM2D3 (almondex) genes, and further generating a triple knockout line, we found that this group of genes all regulate neurogenesis by regulating embryonic Notch signaling. We further identified that TM2D3, which is associated with late-onset Alzheimer's Disease, is also required for proper function and maintenance of the nervous system in adult flies.
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