News & Updates

News and updates from the Yamamoto lab

Jun 9, 2022

Book Chapter: How to study the function of disease associated variants using flies

We contributed a chapter to a book titled "Notch Signaling Research -Methods and Protocols" which describes how we designed and performed...

May 19, 2022

Highlight: ModelMatcher is now part of Matchmaker Exchange

ModelMatcher has now become the first 'Functional Study Node' of Matchmaker Exchange, a federated network of rare disease related...

Apr 10, 2022

Editorial: The role of Drosophila in human disease research

As the guest editors of the "Role of Drosophila in Human Disease Research (volume 1.0 and 2.0)" Issues of the International Journal of...

Mar 14, 2022

Functional study of rare genetic variants identified in autistic individuals using Drosophila

By studying 79 de novo missense variants identified in individual with autism spectrum disorders in flies through rescue and...

Feb 27, 2022

ModelMatcher: Catalyzing collaborations to study and treat rare and undiagnosed diseases

We report the development of ModelMatcher, a matchmaking tool to facilitate collaborations between scientists and clinicians to...

Dec 14, 2021

Evolutionarily conserved TM2D genes regulate Notch signaling and neuronal function in Drosophila

By generating the first clean knockout alleles of the fly genes that correspond to human TM2D1 (biscotti), TM2D2 (amaretto) and TM2D3...

Jul 14, 2021

Highlight: RNF2 story featured on the cover of Human Molecular Genetics

Our research article regarding the discovery of RNF2 as a new neurodevelopment disease causing gene was highlighted on the 2021 July...

Jun 25, 2021

De novo variants in RNF2 causes a novel neurodevelopmental disorder (Luo-Schoch-Yamamoto Syndrome)

We report two pediatric patients with overlapping neurodevelopmental phenotypes who both carry rare de novo missesse variants in RNF2, a...

Mar 8, 2021

Review: Drosophila as a model system to study infectious diseases

We surveyed the literature for papers that investigated the function of pathogenic proteins produced by various viruses and bacteria...